Dennis Kobelt Selected Research

Jet Injections

8/2021	Effective Oncoleaking Treatment of Pancreatic Cancer by Claudin-Targeted Suicide Gene Therapy with Clostridium perfringens Enterotoxin (CPE).
5/2014	Preclinical study on combined chemo- and nonviral gene therapy for sensitization of melanoma using a human TNF-alpha expressing MIDGE DNA vector.
8/2012	Intratumoral dispersion, retention, systemic biodistribution, and clearance of a small-size tumor necrosis factor-α-expressing MIDGE vector after nonviral in vivo jet-injection gene transfer.
11/2008	Novel jet-injection technology for nonviral intratumoral gene transfer in patients with melanoma and breast cancer.
12/2005	Nonviral jet-injection gene transfer for efficient in vivo cytosine deaminase suicide gene therapy of colon carcinoma.

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Dennis Kobelt Research Topics

Disease

30	Neoplasms (Cancer) 03/2022 - 12/2005
22	Neoplasm Metastasis (Metastasis) 03/2022 - 11/2008
8	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 08/2012
7	Colonic Neoplasms (Colon Cancer) 03/2022 - 07/2011
4	Melanoma (Melanoma, Malignant) 01/2022 - 11/2008
4	Carcinoma (Carcinomatosis) 08/2021 - 12/2005
2	Necrosis 08/2021 - 01/2017
1	Neuroblastoma 03/2022
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022
1	Lung Neoplasms (Lung Cancer) 01/2022
1	Obesity 01/2022
1	Papillary Thyroid Cancer 01/2022
1	Pancreatic Neoplasms (Pancreatic Cancer) 08/2021
1	Virus Diseases (Viral Diseases) 10/2020
1	Glioblastoma (Glioblastoma Multiforme) 06/2019
1	Brain Neoplasms (Brain Tumor) 06/2019
1	Ovarian Neoplasms (Ovarian Cancer) 01/2019
1	Communicable Diseases (Infectious Diseases) 12/2012
1	Hyperthermia 10/2010
1	Breast Neoplasms (Breast Cancer) 11/2008

Drug/Important Bio-Agent (IBA)

13	Biomarkers (Surrogate Marker)IBA 03/2022 - 06/2017
6	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 12/2005
5	Proteins (Proteins, Gene)FDA Link 12/2018 - 12/2005
4	Messenger RNA (mRNA)IBA 03/2022 - 12/2005
4	Clostridium enterotoxinIBA 01/2022 - 01/2015
4	ClaudinsIBA 01/2022 - 01/2015
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2022 - 01/2016
2	AZD 6244IBA 03/2022 - 01/2021
2	Calcium-Binding ProteinsIBA 01/2022 - 07/2011
2	Bacterial ToxinsIBA 01/2022 - 01/2017
2	Claudin-3IBA 01/2022 - 01/2017
2	CateninsIBA 12/2021 - 06/2016
2	Pharmaceutical PreparationsIBA 01/2021 - 01/2020
2	Small Interfering RNA (siRNA)IBA 06/2016 - 08/2012
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2014 - 08/2012
2	Cytosine DeaminaseIBA 10/2010 - 12/2005
1	Tight Junction ProteinsIBA 01/2022
1	Claudin-1IBA 01/2022
1	AzoxymethaneIBA 01/2022
1	Insulin-Like PeptidesIBA 11/2021
1	Complementary DNA (cDNA)IBA 01/2021
1	trametinibIBA 01/2021
1	Tyrosine (L-Tyrosine)FDA Link 01/2021
1	RNA (Ribonucleic Acid)IBA 10/2020
1	Biological ProductsIBA 06/2020
1	Adenosine Triphosphate (ATP)IBA 01/2020
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2020
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2020
1	S100 Calcium-Binding Protein A4IBA 01/2019
1	Transcription Factors (Transcription Factor)IBA 12/2018
1	rottlerinIBA 06/2017
1	Lovastatin (Mevacor)FDA LinkGeneric 06/2017
1	Claudin-4IBA 01/2017
1	Vitamin D FDA LinkGeneric 01/2016
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2016
1	Vindesine (Vindesin)IBA 05/2014
1	DNA VaccinesIBA 12/2012
1	VaccinesIBA 12/2012
1	Firefly LuciferasesIBA 08/2012
1	Niclosamide FDA Link 07/2011
1	SolventsIBA 07/2011
1	LuciferasesIBA 07/2011
1	5-bromo-4-chloro-3-indolyl beta-galactoside (X-gal)IBA 11/2008
1	Flucytosine (Ancobon)FDA Link 12/2005

Therapy/Procedure

14	Therapeutics 03/2022 - 08/2012
5	Jet Injections 08/2021 - 12/2005
3	Drug Therapy (Chemotherapy) 08/2021 - 12/2015
1	Transplantation 01/2022